All Curated Mutation Sites in HBV

The VM annotation module provides researchers who are interested in VMs with annotations of reported pathogenic mutations in HBV related to human diseases easily. The curated mutation information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


Browse Data by Virus Gene/Protein/Region or Disease
*Please select one option you are interested in, the page will be automatically redirected.
          
          


S1 Promoter
|
PreS1
|
S2 Promoter
|
PreS2
|
PreS
|
S PromoterII
|
S
|
RT
|
P
|
X Promoter
|
X
|
EnhI
|
EnhII
|
BCP
|
PreC
|
C Promoter
|
C
|

ID PMID Mutation Gene/Protein/Region Description Detail
1 33446224 V173L
RT
D
G
R
S
CI
C
View
2 33446224 L180M
RT
D
G
R
S
CI
C
View
3 33446224 S202I
RT
D
G
R
S
CI
C
View
4 33446224 M204V
RT
D
G
R
S
CI
C
View
5 33446224 M204I
RT
D
G
R
S
CI
C
View
6 19065672 A181T
RT
D
G
S
CI
C
View
7 19065672 A181V
RT
D
G
S
CI
C
View
8 19065672 N236T
RT
D
G
S
CI
C
View
9 20119580 A181T
RT
D
G
R
CI
C
View
10 20119580 A181V
RT
D
G
R
CI
C
View
11 23710315 A181V
RT
D
G
R
CI
C
View
12 23710315 S202G
RT
D
G
R
CI
C
View
13 24637457 L80*
RT
D
G
R
S
C
View
14 24637457 I169N
RT
D
G
R
S
C
View
15 24637457 V173L
RT
D
G
R
S
C
View
16 24637457 L180*
RT
D
G
R
S
C
View
17 24637457 A181G
RT
D
G
R
S
C
View
18 24637457 S202I
RT
D
G
R
S
C
View
19 24637457 M204V
RT
D
G
R
S
C
View
20 24637457 Q215S
RT
D
G
R
S
C
View
21 24637457 I233V
RT
D
G
R
S
C
View
22 24637457 N236I
RT
D
G
R
S
C
View
23 24637457 M250V
RT
D
G
R
S
C
View
24 25503289 C400A
RT
G
R
S
I
C
View
25 25503289 T472G
RT
G
R
S
I
C
View
26 25503289 A533C
RT
G
R
S
I
C
View
27 25503289 A533T
RT
G
R
S
I
C
View
28 25503289 A793T
RT
G
R
S
I
C
View
29 25503289 C823A
RT
G
R
S
I
C
View
30 25503289 A871C
RT
G
R
S
I
C
View
31 25503289 T895A
RT
G
R
S
I
C
View
32 25503289 T918A
RT
G
R
S
I
C
View
33 25503289 T926G
RT
G
R
S
I
C
View
34 25503289 T926A
RT
G
R
S
I
C
View
35 25503289 G950A
RT
G
R
S
I
C
View
36 25503289 A965C
RT
G
R
S
I
C
View
37 25503289 T1055A
RT
G
R
S
I
C
View
38 25503289 A853C
RT
G
R
S
I
C
View
39 25503289 C888A
RT
G
R
S
I
C
View
40 25503289 A906C
RT
G
R
S
I
C
View
41 25503289 T907A
RT
G
R
S
I
C
View
42 25503289 T907C
RT
G
R
S
I
C
View
43 25503289 G909A
RT
G
R
S
I
C
View
44 25503289 G969A
RT
G
R
S
I
C
View
45 25503289 C987G
RT
G
R
S
I
C
View
46 25503289 C987T
RT
G
R
S
I
C
View
47 25503289 C987A
RT
G
R
S
I
C
View
48 25503289 G852A
RT
G
R
S
I
C
View
49 25503289 C406T
RT
G
R
S
I
C
View
50 25503289 A436G
RT
G
R
S
I
C
View
51 25503289 G779T
RT
G
R
S
I
C
View
52 25503289 A886G
RT
G
R
S
I
C
View
53 25503289 A952G
RT
G
R
S
I
C
View
54 25503289 C885T
RT
G
R
S
I
C
View
55 25503289 A903G
RT
G
R
S
I
C
View
56 25503289 G933A
RT
G
R
S
I
C
View
57 25503289 A987C
RT
G
R
S
I
C
View
58 25503289 A994C
RT
G
R
S
I
C
View
59 25503289 L91I
RT
G
R
S
I
C
View
60 25503289 H94I
RT
G
R
S
I
C
View
61 25503289 R110G
RT
G
R
S
I
C
View
62 25503289 L115V
RT
G
R
S
I
C
View
63 25503289 F122I
RT
G
R
S
I
C
View
64 25503289 H124Y
RT
G
R
S
I
C
View
65 25503289 Y135S
RT
G
R
S
I
C
View
66 25503289 Y135F
RT
G
R
S
I
C
View
67 25503289 S137T
RT
G
R
S
I
C
View
68 25503289 L145M
RT
G
R
S
I
C
View
69 25503289 R153K
RT
G
R
S
I
C
View
70 25503289 R153Q
RT
G
R
S
I
C
View
71 25503289 S219P
RT
G
R
S
I
C
View
72 25503289 F221Y
RT
G
R
S
I
C
View
73 25503289 T222S
RT
G
R
S
I
C
View
74 25503289 P237T
RT
G
R
S
I
C
View
75 25503289 N248H
RT
G
R
S
I
C
View
76 25503289 C256S
RT
G
R
S
I
C
View
77 25503289 D263E
RT
G
R
S
I
C
View
78 25503289 I266K
RT
G
R
S
I
C
View
79 25503289 R274K
RT
G
R
S
I
C
View
80 25503289 N279T
RT
G
R
S
I
C
View
81 25503289 M309K
RT
G
R
S
I
C
View
82 25503289 V142V
RT
G
R
S
I
C
View
83 25503289 L168L
RT
G
R
S
I
C
View
84 25503289 H117H
RT
G
R
S
I
C
View
85 25503289 Q215Q
RT
G
R
S
I
C
View
86 25503289 R242R
RT
G
R
S
I
C
View
87 25503289 V253V
RT
G
R
S
I
C
View
88 25503289 S259S
RT
G
R
S
I
C
View
89 25503289 L260L
RT
G
R
S
I
C
View
90 25503289 R280R
RT
G
R
S
I
C
View
91 25503289 V286V
RT
G
R
S
I
C
View
92 25503289 Y135H
RT
G
R
S
I
C
View
93 25503289 I163V
RT
G
R
S
I
C
View
94 25503289 S213T
RT
G
R
S
I
C
View
95 25503289 V214D
RT
G
R
S
I
C
View
96 25503289 H134H
RT
G
R
S
I
C
View
97 25503289 V208V
RT
G
R
S
I
C
View
98 25503289 A211A
RT
G
R
S
I
C
View
99 25503289 K241K
RT
G
R
S
I
C
View
100 25503289 L93F
RT
G
R
S
I
C
View
101 25503289 I103V
RT
G
R
S
I
C
View
102 25503289 L217R
RT
G
R
S
I
C
View
103 25503289 I253V
RT
G
R
S
I
C
View
104 25503289 K275E
RT
G
R
S
I
C
View
105 25503289 Y252Y
RT
G
R
S
I
C
View
106 25503289 G258G
RT
G
R
S
I
C
View
107 25503289 K268K
RT
G
R
S
I
C
View
108 25503289 R289R
RT
G
R
S
I
C
View
109 28500726 A194T
RT
D
G
R
S
C
View
110 28500726 L180M
RT
D
G
R
S
C
View
111 28500726 L80I
RT
D
G
R
S
C
View
112 28500726 L80V
RT
D
G
R
S
C
View
113 28500726 M204I
RT
D
G
R
S
C
View
114 28500726 M204V
RT
D
G
R
S
C
View
115 31248149 H271C
RT
D
G
R
CI
C
View
116 31248149 I121N
RT
D
G
R
CI
C
View
117 31248149 I163V
RT
D
G
R
CI
C
View
118 31248149 K270R
RT
D
G
R
CI
C
View
119 31248149 L140P
RT
D
G
R
CI
C
View
120 31248149 L217R
RT
D
G
R
CI
C
View
121 31248149 L220I
RT
D
G
R
CI
C
View
122 31248149 M129L
RT
D
G
R
CI
C
View
123 31248149 N238H
RT
D
G
R
CI
C
View
124 31248149 P237H
RT
D
G
R
CI
C
View
125 31248149 R110G
RT
D
G
R
CI
C
View
126 31248149 R138E
RT
D
G
R
CI
C
View
127 31248149 R138K
RT
D
G
R
CI
C
View
128 31248149 R242K
RT
D
G
R
CI
C
View
129 31248149 R280S
RT
D
G
R
CI
C
View
130 31248149 S117C
RT
D
G
R
CI
C
View
131 31248149 S117Y
RT
D
G
R
CI
C
View
132 31248149 T128I
RT
D
G
R
CI
C
View
133 31248149 T128S
RT
D
G
R
CI
C
View
134 31248149 T225I
RT
D
G
R
CI
C
View
135 31248149 T259S
RT
D
G
R
CI
C
View
136 31248149 V142A
RT
D
G
R
CI
C
View
137 31248149 V278I
RT
D
G
R
CI
C
View
138 31248149 W153R
RT
D
G
R
CI
C
View
139 31248149 Y126H
RT
D
G
R
CI
C
View
140 31248149 N122H
RT
D
G
R
CI
C
View
141 31248149 P109S
RT
D
G
R
CI
C
View
142 31248149 S105T
RT
D
G
R
CI
C
View
143 31248149 N76D
RT
D
G
R
CI
C
View
144 31248149 V266R
RT
D
G
R
CI
C
View
145 31248149 V253I
RT
D
G
R
CI
C
View
146 31248149 V266I
RT
D
G
R
CI
C
View
147 31248149 L129M
RT
D
G
R
CI
C
View
148 31248149 Q125E
RT
D
G
R
CI
C
View
149 31248149 H271Y
RT
D
G
R
CI
C
View
150 32216026 L180M
RT
D
G
R
S
C
View
151 32216026 M204V
RT
D
G
R
S
C
View
152 32216026 T184A
RT
D
G
R
S
C
View
153 32216026 T184L
RT
D
G
R
S
C
View
154 32216026 S202G
RT
D
G
R
S
C
View
155 32216026 M250V
RT
D
G
R
S
C
View
156 32216026 I169T
RT
D
G
R
S
C
View
157 33381105 L180M
RT
D
G
R
S
C
View
158 33381105 M204V
RT
D
G
R
S
C
View
159 33381105 A181T
RT
D
G
R
S
C
View
160 33381105 A181V
RT
D
G
R
S
C
View
161 33381105 T184G
RT
D
G
R
S
C
View
162 33381105 T184S
RT
D
G
R
S
C
View
163 33381105 S202G
RT
D
G
R
S
C
View
164 33381105 S202I
RT
D
G
R
S
C
View
165 33381105 M204I
RT
D
G
R
S
C
View
166 33381105 N236T
RT
D
G
R
S
C
View
167 33381105 M250V
RT
D
G
R
S
C
View
168 33571155 A181V
RT
D
G
S
CI
C
View
169 33571155 T184A
RT
D
G
S
CI
C
View
170 33571155 S202G
RT
D
G
S
CI
C
View
171 33571155 M204V
RT
D
G
S
CI
C
View
172 33571155 L180M
RT
D
G
S
CI
C
View
173 33836203 Y124H
RT
G
R
S
CI
C
View
174 15953865 M204I
RT
D
G
R
C
View
175 16789011 L180M
RT
D
G
R
C
View
176 16789011 M204I
RT
D
G
R
C
View
177 16789011 M204V
RT
D
G
R
C
View
178 17506609 L180M
RT
D
G
S
C
View
179 17506609 M204V
RT
D
G
S
C
View
180 17506609 V173L
RT
D
G
S
C
View
181 18036224 L180M
RT
D
G
S
C
View
182 18036224 M204V
RT
D
G
S
C
View
183 18036224 V173L
RT
D
G
S
C
View
184 18171343 L180M
RT
D
G
S
C
View
185 18171343 M204I
RT
D
G
S
C
View
186 18171343 M204V
RT
D
G
S
C
View
187 18171343 S117Y
RT
D
G
S
C
View
188 18171343 V142A
RT
D
G
S
C
View
189 18171343 S117C
RT
D
G
S
C
View
190 18171343 G743C
RT
D
G
S
C
View
191 18171343 A741G
RT
D
G
S
C
View
192 18211717 L180M
RT
D
G
S
C
View
193 18211717 M204V
RT
D
G
S
C
View
194 18211717 M204I
RT
D
G
S
C
View
195 18211717 L180I
RT
D
G
S
C
View
196 18713056 L180M
RT
D
G
R
S
View
197 18713056 M204I
RT
D
G
R
S
View
198 18713056 M204V
RT
D
G
R
S
View
199 18713056 V173L
RT
D
G
R
S
View
200 18713056 L82M
RT
D
G
R
S
View
201 18713056 N118K
RT
D
G
R
S
View
202 18713056 V184D
RT
D
G
R
S
View
203 19041149 N139K
RT
D
G
I
C
View
204 19125938 L180M
RT
D
G
S
C
View
205 19125938 M204I
RT
D
G
S
C
View
206 19125938 M204V
RT
D
G
S
C
View
207 19125938 T184L
RT
D
G
S
C
View
208 19272629 T473C
RT
G
R
CI
C
View
209 19272629 L461S
RT
G
R
CI
C
View
210 19272629 Y470N
RT
G
R
CI
C
View
211 19889143 V112I
RT
G
R
S
C
View
212 19889143 I103T
RT
G
R
S
C
View
213 19889143 C136Y
RT
G
R
S
C
View
214 19889143 W153C
RT
G
R
S
C
View
215 19889143 L66F
RT
G
R
S
C
View
216 19889143 R153Q
RT
G
R
S
C
View
217 19889143 V63A
RT
G
R
S
C
View
218 19889143 T70A
RT
G
R
S
C
View
219 19889143 H94R
RT
G
R
S
C
View
220 21063484 N131S
RT
G
R
S
C
View
221 21063484 Y141F
RT
G
R
S
C
View
222 21063484 M145V
RT
G
R
S
C
View
223 21392168 A181V
RT
D
G
S
C
View
224 21392168 L180M
RT
D
G
S
C
View
225 21392168 M204I
RT
D
G
S
C
View
226 21392168 M204V
RT
D
G
S
C
View
227 21392168 N236T
RT
D
G
S
C
View
228 21392168 S202G
RT
D
G
S
C
View
229 21392168 V173L
RT
D
G
S
C
View
230 21392168 A181T
RT
D
G
S
C
View
231 21392168 A181S
RT
D
G
S
C
View
232 21392168 M250L
RT
D
G
S
C
View
233 21392168 V173M
RT
D
G
S
C
View
234 21392168 T184S
RT
D
G
S
C
View
235 21392168 V214A
RT
D
G
S
C
View
236 21671883 L180M
RT
D
G
S
C
View
237 21671883 M204I
RT
D
G
S
C
View
238 21671883 M204V
RT
D
G
S
C
View
239 22001270 M204I
RT
D
G
R
C
View
240 22001270 M204V
RT
D
G
R
C
View
241 22001270 N124D
RT
D
G
R
C
View
242 22001270 S117F
RT
D
G
R
C
View
243 22138714 N238H
RT
D
G
R
C
View
244 22138714 L180M
RT
D
G
R
C
View
245 22138714 N236T
RT
D
G
R
C
View
246 22170539 L229V
RT
G
R
S
C
View
247 22170539 V191I
RT
G
R
S
C
View
248 22195774 M204I
RT
D
G
R
CI
View
249 22195774 M204V
RT
D
G
R
CI
View
250 22510826 M204V
RT
D
G
S
C
View
251 22592516 M204V
RT
D
S
CI
C
View
252 22720023 A181T
RT
D
G
S
C
View
253 23029487 L180M
RT
R
S
CI
C
View
254 23029487 M204V
RT
R
S
CI
C
View
255 23029487 V173L
RT
R
S
CI
C
View
256 23029487 V214A
RT
R
S
CI
C
View
257 23029487 E1D
RT
R
S
CI
C
View
258 23029487 S105T
RT
R
S
CI
C
View
259 23029487 H122N
RT
R
S
CI
C
View
260 23029487 Q125E
RT
R
S
CI
C
View
261 23114756 A181T
RT
D
S
CI
C
View
262 23114756 L180M
RT
D
S
CI
C
View
263 23114756 L80I
RT
D
S
CI
C
View
264 23114756 L80V
RT
D
S
CI
C
View
265 23114756 M204I
RT
D
S
CI
C
View
266 23114756 M204V
RT
D
S
CI
C
View
267 23114756 V173L
RT
D
S
CI
C
View
268 23114756 M204M
RT
D
S
CI
C
View
269 23114756 L80L
RT
D
S
CI
C
View
270 23114756 M204L
RT
D
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RT
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4979 17178796 A200V
RT
View
4980 17178796 L80V
RT
View
4981 17178796 K168E
RT
View
4982 17178796 A181T
RT
View
4983 17178796 C188S
RT
View
4984 17178796 L180T
RT
View
4985 17178796 V224A
RT
View
4986 17178796 L228P
RT
View
4987 17178796 L229W
RT
View
4988 17178796 D263G
RT
View
4989 17178796 M309L
RT
View
4990 17438047 V173L
RT
View
4991 17692425 V84M
RT
View
4992 17692425 S185T
RT
View
4993 17692425 Y327S
RT
View
4994 17692425 H94N
RT
View
4995 17692425 N36D
RT
View
4996 17692425 A181T
RT
View
4997 17692425 L180M
RT
View
4998 17692425 M204V
RT
View
4999 17713159 L180M
RT
View
5000 17713159 M204S
RT
View
5001 18431229 M204I
RT
View
5002 18431229 M204V
RT
View
5003 18435459 T184R
RT
View
5004 18435459 T184W
RT
View
5005 18435459 M250P
RT
View
5006 18571815 D205A
RT
View
5007 19008175 S219A
RT
View
5008 19107976 L80I
RT
View
5009 19107976 L80V
RT
View
5010 19195324 S219A
RT
View
5011 19669299 I233V
RT
View
5012 19669299 M250L
RT
View
5013 19795617 L180M
RT
View
5014 19795617 Q215S
RT
View
5015 20516567 A181T
RT
View
5016 20944991 L180M
RT
View
5017 20944991 V173L
RT
View
5018 21831732 A181T
RT
View
5019 21831732 A181V
RT
View
5020 21831732 A194T
RT
View
5021 21831732 I169T
RT
View
5022 21831732 L180M
RT
View
5023 21831732 L80I
RT
View
5024 21831732 L80V
RT
View
5025 21831732 M204I
RT
View
5026 21831732 M204V
RT
View
5027 21831732 V173L
RT
View
5028 21831732 G173L
RT
View
5029 21831732 K180M
RT
View
5030 21831732 Q215S
RT
View
5031 21831732 P215S
RT
View
5032 21831732 H215S
RT
View
5033 21831732 V191I
RT
View
5034 21831732 A181S
RT
View
5035 21860069 M204I
RT
View
5036 22082274 M204I
RT
View
5037 22082274 M204V
RT
View
5038 23403838 C669A
RT
View
5039 23403838 A741G
RT
View
5040 23403838 A194T
RT
View
5041 23805155 L180M
RT
View
5042 23805155 M204V
RT
View
5043 24053482 M204I
RT
View
5044 24053482 M204V
RT
View
5045 25318660 S202I
RT
View
5046 25318660 S202G
RT
View
5047 25318660 S202R
RT
View
5048 25318660 A181V
RT
View
5049 25318660 A181T
RT
View
5050 25318660 A194T
RT
View
5051 25318660 L180M
RT
View
5052 25318660 V173L
RT
View
5053 25318660 L80I
RT
View
5054 25318660 N236T
RT
View
5055 25318660 I169T
RT
View
5056 25318660 T184G
RT
View
5057 25318660 M250V
RT
View
5058 25318660 M250L
RT
View
5059 26201776 A181V
RT
View
5060 26220282 M204A
RT
View
5061 26220282 M204K
RT
View
5062 26220282 M204L
RT
View
5063 26220282 M204R
RT
View
5064 26220282 M204T
RT
View
5065 26220282 L180M
RT
View
5066 26336997 A194T
RT
View
5067 26336997 L180M
RT
View
5068 26336997 N236T
RT
View
5069 26336997 S202G
RT
View
5070 26349829 Y63F
RT
View
5071 26524917 L180M
RT
View
5072 26524917 L80I
RT
View
5073 26524917 M204I
RT
View
5074 26524917 M204V
RT
View
5075 26567840 A181T
RT
View
5076 27386641 M204I
RT
View
5077 27588233 M204I
RT
View
5078 27588233 M204V
RT
View
5079 27871021 M204V
RT
View
5080 27919846 A181T
RT
View
5081 27919846 M204I
RT
View
5082 27919846 V191I
RT
View
5083 27976732 A181T
RT
View
5084 29039614 L228W
RT
View
5085 29039614 L229W
RT
View
5086 29039614 L180M
RT
View
5087 29039614 M204V
RT
View
5088 29039614 M204I
RT
View
5089 29609638 A181T
RT
View
5090 29669831 Y63F
RT
View
5091 29713126 R242A
RT
View
5092 30179704 S137Q
RT
View
5093 30179704 N139K
RT
View
5094 30202825 V181C
RT
View
5095 30202825 L173V
RT
View
5096 30202825 H13L
RT
View
5097 30202825 R18K
RT
View
5098 30202825 N53K
RT
View
5099 30202825 N53H
RT
View
5100 30202825 N123H
RT
View
5101 30202825 V142A
RT
View
5102 30202825 C188L
RT
View
5103 30202825 V214A
RT
View
5104 30202825 V214I
RT
View
5105 30202825 V214P
RT
View
5106 30202825 L220I
RT
View
5107 30202825 A329S
RT
View
5108 30202825 I187V
RT
View
5109 30202825 K318R
RT
View
5110 30202825 W257H
RT
View
5111 30202825 S78C
RT
View
5112 30202825 Q125K
RT
View
5113 30202825 V142G
RT
View
5114 30202825 S40A
RT
View
5115 30202825 L247F
RT
View
5116 30202825 L229F
RT
View
5117 30202825 L229V
RT
View
5118 30202825 L164F
RT
View
5119 30202825 S135F
RT
View
5120 30202825 R280G
RT
View
5121 30202825 Q267N
RT
View
5122 30202825 R153Q
RT
View
5123 30202825 Q271V
RT
View
5124 30202825 F273L
RT
View
5125 30202825 S78T
RT
View
5126 30202825 Q267R
RT
View
5127 30202825 H13S
RT
View
5128 30202825 Q267M
RT
View
5129 30202825 L80I
RT
View
5130 30202825 N131G
RT
View
5131 30202825 Q316H
RT
View
5132 30202825 T128N
RT
View
5133 30202825 A186T
RT
View
5134 30202825 V207I
RT
View
5135 30202825 L229W
RT
View
5136 30202825 A181A
RT
View
5137 30202825 A181G
RT
View
5138 30202825 A181N
RT
View
5139 30202825 A181S
RT
View
5140 30202825 A181T
RT
View
5141 30202825 A186S
RT
View
5142 30202825 E263A
RT
View
5143 30202825 R242S
RT
View
5144 30202825 R289S
RT
View
5145 30202825 I290L
RT
View
5146 30202825 C332Y
RT
View
5147 30202825 A62T
RT
View
5148 30202825 Q215R
RT
View
5149 31218588 A181T
RT
View
5150 31218588 M204I
RT
View
5151 31218588 V191I
RT
View
5152 32650547 Y63F
RT
View
5153 32702076 R105A
RT
View
5154 32868329 L180Q
RT
View
5155 32887289 M204I
RT
View
5156 32887289 A181T
RT
View
5157 32894807 L269I
RT
View
5158 32987867 L180M
RT
View
5159 32987867 T184L
RT
View
5160 32987867 M204V
RT
View
5161 32987867 A200V
RT
View
5162 32987867 S106C
RT
View
5163 32987867 H126Y
RT
View
5164 32987867 D134E
RT
View
5165 32987867 L269I
RT
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
Drugs mentioned in the relevant literature.
G
Genotypes/subtypes mentioned in the relevant literature.
R
Reference genomes mentioned in the relevant literature.
S
Viral sequences mentioned in the relevant literature.
C
Geographical distribution of the source mentioned in the relevant literature.
CI
Clinical information is available in the relevant literature.
I
This mutation is related to the immune escape.

Copyright © 2021.Tongji University, Life Science and Technology Department, Xiaoyan Zhang Lab.