Mutation Information
Mutation Site
|
M204V |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
lamivudine (LAM) |
Literature Information
PubMed PMID
|
15980328
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2005 |
Journal
|
Antimicrobial agents and chemotherapy |
Title
|
Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy. |
Author
|
Pai SB,Bozdayi AM,Pai RB,Beker T,Sarioglu M,Turkyilmaz AR,Grier J,Yurdaydin C,Schinazi RF |
Evidence
|
The virus with rtM204V can also acquire rtL180M change and these are the most common genotypes seen in the clinic in response to long term lamivudine therapy.
|
|
|