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Mutation Information
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Mutation Site
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S256G |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.S256G+rt.N238A;rt.S256G+rt.S213T+rt.V207M;rt.S256G+rt.S213T+rt.V207M+rt.I187V |
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Relevant Drug
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lamivudine (LAM);adefovir dipivoxil (ADV);tenofovir (TDF);entecavir (ETV) |
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Country
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Vietnam |
Literature Information
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PubMed PMID
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32708399
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Disease
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Chronic hepatitis B
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Published Year
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2020 |
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Journal
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Diagnostics (Basel, Switzerland) |
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Title
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COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B. |
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Author
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Phung TTB,Chu SV,Vu ST,Pham HT,Nguyen HM,Nguyen HD,Le NT,Nguyen DV,Truong PT,Vu VTT,Nguyen ATV |
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Evidence
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Multiple-point mt were found only in 8 cases (5.6%): 6 children carried double mt (rtV207M + rtL229V; rtV207M + rtI233V; rtV207I + rtV207M x 2 cases; rtV207M + rtS213T; rtN238A + rtS256G) relating to LMV or/and ADF resistance and 3 children carried triple mt (rtL180M + rtM204I + rtN238T; rtV207M + rtS213T + rtS256G) or quadruple mt (rtL180M + rtM204V + rtV207I/M) for LMV-ADF resistance and Entecavir-reduced susceptibility.
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HBV Mutation Detail Information