HBV Mutation Detail Information

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Mutation Information

Mutation Site	D134N
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	C
Viral Reference	GQ872210
Country	Japan

Literature Information

PubMed PMID	33462964
Disease	Chronic hepatitis B
Published Year	2021
Journal	Hepatology research : the official journal of the Japan Society of Hepatology
Title	Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.
Author	Suzuki F,Sezaki H,Hosaka T,Suzuki Y,Fujiyama S,Kawamura Y,Akuta N,Kobayashi M,Saitoh S,Arase Y,Ikeda K,Kobayashi M,Mineta R,Suzuki Y,Kumada H
Evidence	Four mutations (rtS106C, rtD134N/S[N/S], rtM204V, and rtL269I) plus ETV resistance (rtL180M and rtS202G) existed when she developed viral breakthrough during ETV and TDF combination therapy in April 2013.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation