HBV Mutation Detail Information

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Mutation Information
Mutation Site S202I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.M204V+rt.S202I+rt.T184G+rt.L180M
Genotype/Subtype D
Relevant Drug lamivudine (LAM);entecavir (ETV)
Literature Information
PubMed PMID 18571815
Disease Chronic hepatitis B
Published Year 2008
Journal Hepatology (Baltimore, Md.)
Title Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Author Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA
Evidence Reduced intracellular and extracellular % dDNA was observed for the LMV-R mutants (rtM204I, rtL180M + M204V, and rtL180M + T184G + S202I + M204V), ranging from a 20% to 50% reduction.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation