Mutation Information
Mutation Site
|
S202I |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.M204V+rt.S202I+rt.T184G+rt.L180M |
Genotype/Subtype
|
D |
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
PubMed PMID
|
18571815
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2008 |
Journal
|
Hepatology (Baltimore, Md.) |
Title
|
Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance. |
Author
|
Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA |
Evidence
|
Reduced intracellular and extracellular % dDNA was observed for the LMV-R mutants (rtM204I, rtL180M + M204V, and rtL180M + T184G + S202I + M204V), ranging from a 20% to 50% reduction.
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