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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M+rt.V173L;rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);emtricitabine (FTC) |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
18167643
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2007 |
|
Journal
|
Journal of acquired immune deficiency syndromes (1999) |
|
Title
|
Selection of hepatitis B virus (HBV) vaccine escape mutants in HBV-infected and HBV/HIV-coinfected patients failing antiretroviral drugs with anti-HBV activity. |
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Author
|
Sheldon J,Ramos B,Garcia-Samaniego J,Rios P,Bartholomeusz A,Romero M,Locarnini S,Zoulim F,Soriano V |
|
Evidence
|
The triple-HBV mutant rtV173L + rtL180M + rtM204V, which has been shown to produce a diminished hepatitis B surface (HBs) antigen-antibody binding, was found in 3 individuals, all coinfected with HIV and HBV.
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HBV Mutation Detail Information