Mutation Information
Mutation Site
|
M204V |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.M204I+rt.M204V;rt.M204V;rt.M204V+rt.M204I;rt.M250L+rt.M250I+rt.M250V+rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V;rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V;rt.M250L+rt.M250I+rt.M250V+rt.M204I+rt.M204V;rt.M204I+rt.M204V+rt.N236T+rt.A181V;rt.A181V+rt.M204I+rt.M204V;rt.N236T+rt.M204I+rt.M204V;rt.M250L+rt.M250I+rt.M250V+rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V+rt.N236T+rt.A181V;rt.M204V+rt.A181V+rt.L180M;rt.N236T+rt.M204V+rt.S202G+rt.L180M;rt.N236T+rt.M204V+rt.T184A+rt.L180M;rt.N236T+rt.M204V+rt.A181V+rt.L180M+rt.L80I |
Genotype/Subtype
|
B;C |
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Country
|
China |
Literature Information
PubMed PMID
|
27792585
|
Disease
|
HBV infection
|
Published Year
|
2017 |
Journal
|
Microbial drug resistance (Larchmont, N.Y.) |
Title
|
Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China. |
Author
|
Li X,Liu Y,Xin S,Ji D,You S,Hu J,Zhao J,Wu J,Liao H,Zhang XX,Xu D |
Evidence
|
For entecavir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtM204 V/I+T184 substitution or S202G/C (3.66% vs. 2.16%, p < 0.01) and a lower detection rate of rtM204 V/I+M250 V/I/L substitution (0.67% vs. 1.46%, p < 0.01).
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