HBV Mutation Detail Information

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Mutation Information
Mutation Site I601V
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Country Iran
Literature Information
PubMed PMID 31179360
Disease Chronic hepatitis B
Published Year 2019
Journal Virusdisease
Title Hepatitis B virus reverse transcriptase polymorphisms between treated and treatment-naïve chronically infected patients.
Author Rezanezhadi M,Mohebbi A,Askari FS,Hosseini SD,Tabarraei A
Evidence FI score of HBV polymerase substitution. Substitutions with low FI were Y592F (0.895), Y592H (0.895), E598N (1.15), H599R (1.67), Q602H (0.805), Q602P (1.15), K603R (1.845), R609I (1.525), L611H (1.67), P616T (1.845), C622G (1.845), I625M (1.67), V626G (1.525), L628F (1.67), G630A (1.67), F631L (1.845), and A632C (1.445). L629G/W had medium functional impact with FI score of 1.975. Further neutral substitutions with FI score of 0 were G442L, S444P, L457F, N459H/Y, M464L, P465Q/H, D466K/N, Y470S/L, L481S, H491Q, F501L, R502Q, L515M, A521V, I522L, V526I, A529V, M539V, D541E, S548T/N, V549A/E, Q550H/S/P, L552H/R, S554A, F556Y, V559A, I568V, N573H/S, K574R, K576Q, Y580H, N583H, I589G, E598D, and I601R. Further neutral substitutions were C591S (− 1.1), I601K/M (0.69), I601V (− 0.625), Q602L (0.255), E606D/K (0.345), and I613V (− 1.355)

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation