|
Mutation Information
|
Mutation Site
|
V173L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
22510826
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2012 |
|
Journal
|
Memorias do Instituto Oswaldo Cruz |
|
Title
|
Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes. |
|
Author
|
Mello FC,Fernandes CA,Gomes Sde A |
|
Evidence
|
Single mutation (rtM204V/I) occurred exclusively in five of nine YIDD variants, while double (rtL180M, rtM204V/I) or triple (rtV173L, rtL180M, rtM204V/I) mutations occurred in all 18 YVDD variants (p = 0.002) (Figure, Table IV).
|
|
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HBV Mutation Detail Information