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Mutation Information
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Mutation Site
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W153Q |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Genotype/Subtype
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B;C;D |
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Relevant Drug
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lamivudine (LAM) |
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Country
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South Korea;Indonesia;China;India |
Literature Information
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PubMed PMID
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29713126
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Published Year
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2018 |
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Journal
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World journal of gastroenterology |
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Title
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Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression. |
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Author
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Choi YM,Lee SY,Kim BJ |
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Evidence
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A total of 26 types of RT mutations, including rtS53N, rtT54N, rtL82M, rtV84M, rtS85A, rtI91L, rtY126C, rtT128I/N, rtN139D, rtW153Q, rtF166L, rtV191I, rtA200V, rtV207I, rtS213T, rtV214A, rtQ215P/S, rtL217R, rtE218D, rtF221Y, rtL229G/V/W, rtI233V, rtP237H, rtN238D/S/T, rtY245H, and rtS/C256G, are considered putative drug resistance mutations (Category 3) (Table (Table11);Our literature based pooled incidence data showed that several putative or pretreatment mutations, including rtI91L, mutations in 6 positions of A-B interdomain (rtY124H, rtY126C/R/H, rtT128I/N, rtD134E/N, rtN139D/E/H/K/Q and rtW153Q/R/E), rtF221Y and rtI224V, were encountered with high frequency from the treatment naïve patients
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HBV Mutation Detail Information