|
Mutation Information
|
Mutation Site
|
S78T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.S78T+rt.S6*;rt.S78T+rt.I16T+rt.D7T+rt.L4I+rt.E10D;rt.S78T+rt.D7A+rt.L4I+rt.E10D |
|
Viral Reference
|
AY741797.1
|
|
Relevant Drug
|
entecavir (ETV);tenofovir (TDF) |
|
Country
|
Germany |
Literature Information
|
PubMed PMID
|
28392234
|
|
Disease
|
HBV infection
|
|
Published Year
|
2017 |
|
Journal
|
Journal of hepatology |
|
Title
|
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy. |
|
Author
|
Shirvani-Dastgerdi E,Winer BY,Celià-Terrassa T,Kang Y,Tabernero D,Yagmur E,Rodríguez-Frías F,Gregori J,Luedde T,Trautwein C,Ploss A,Tacke F |
|
Evidence
|
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
|
|
|
HBV Mutation Detail Information