HBV Mutation Detail Information

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Mutation Information

Mutation Site	L229F
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	lamivudine (LAM)
Country	beijing;China

Literature Information

PubMed PMID	22398037
Disease	Chronic hepatitis B
Published Year	2012
Journal	Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Title	The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutation.
Author	Ji D,Liu Y,Li L,Xu Z,Si LL,Dai JZ,Li X,Wang L,Yao Z,Xin SJ,Chen GF,Xu D
Evidence	Replication-competent viral amplicons which harbored HBV genomes of wild-type, rtM204I, or rtM204I in conjunction with various rtL229 substitutions (rtL229F/W/M/V) were constructed.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation