|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
19280622
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2009 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy. |
|
Author
|
Tenney DJ,Rose RE,Baldick CJ,Pokornowski KA,Eggers BJ,Fang J,Wichroski MJ,Xu D,Yang J,Wilber RB,Colonno RJ |
|
Evidence
|
Entecavir (ETV) resistance (ETVr) results from HBV reverse transcriptase substitutions at positions T184, S202, or M250, which emerge in the presence of lamivudine (LVD) resistance substitutions M204I/V +/- L180M.
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HBV Mutation Detail Information