HBV Mutation Detail Information

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Mutation Information

Mutation Site	M250L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	entecavir (ETV)
Country	Italy

Literature Information

PubMed PMID	21692935
Disease	Chronic hepatitis B
Published Year	2011
Journal	Journal of viral hepatitis
Title	Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B.
Author	Mirandola S,Campagnolo D,Bortoletto G,Franceschini L,Marcolongo M,Alberti A
Evidence	Four patients had the rtI233V mutation that may reduce sensitivity to adefovir, and three patients had the rtM250L/V mutation typical of entecavir resistance.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation