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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L180M+rt.L80V+rt.M204I+rt.M204V;rt.L180M+rt.M204I;rt.L180M+rt.M204V |
|
Genotype/Subtype
|
B;C;D |
Literature Information
|
PubMed PMID
|
17438047
|
|
Published Year
|
2007 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro. |
|
Author
|
Warner N,Locarnini S,Kuiper M,Bartholomeusz A,Ayres A,Yuen L,Shaw T |
|
Evidence
|
The presence of the PC stop codon (G1896A) mutation, which confers HBeAg negativity, enhanced the replication efficiency, whereas the rtL180M substitution in isolation did not significantly affect the replication yield, also confirming previous findings
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|
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HBV Mutation Detail Information