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Mutation Information
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Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rt.M204V+rt.L180M+rt.T128N |
|
Viral Reference
|
AY741797.1
|
|
Country
|
Germany |
Literature Information
|
PubMed PMID
|
28392234
|
|
Disease
|
HBV infection
|
|
Published Year
|
2017 |
|
Journal
|
Journal of hepatology |
|
Title
|
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy. |
|
Author
|
Shirvani-Dastgerdi E,Winer BY,Celià-Terrassa T,Kang Y,Tabernero D,Yagmur E,Rodríguez-Frías F,Gregori J,Luedde T,Trautwein C,Ploss A,Tacke F |
|
Evidence
|
Other mutations, especially those related to LAM or ETV resistance (rtL180M and rtM204V/I) and classical immune escape (sG145R and/or P120T) variants were noted at no or very low frequencies (Table 1), despite ETV treatment [10].
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HBV Mutation Detail Information