HBV Mutation Detail Information

> L180M Search Result


Mutation Information
Mutation Site L180M
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.L180M+rt.M204I;rt.L180M+rt.L80V+rt.L80I+rt.M204I;rt.V173M+rt.L180M+rt.M204I;rt.L180M+rt.M204V;rt.L180M+rt.V173L+rt.M204V;rt.L180M+rt.L80V+rt.L80I+rt.M204V;rt.L180M+rt.V173L+rt.L80V+rt.L80I+rt.M204V;rt.A181T+rt.L180M+rt.M204V+rt.M204I;rt.L180M+rt.L80V+rt.L80I+rt.M204V+rt.M204I;rt.L180M+rt.V173L+rt.L80V+rt.L80I+rt.M204V+rt.M204I
Country China
Literature Information
PubMed PMID 24160943
Disease Chronic hepatitis B
Published Year 2013
Journal Virology journal
Title Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B.
Author Lei J,Wang Y,Wang LL,Zhang SJ,Chen W,Bai ZG,Xu LY
Evidence Among LAM/LdT based therapies, HBV rtM204I was significantly associated with HBV rtL80I/V mutations [rtM204I+rtL80I/V (50.0%, 32/64) vs. rtM204V+rtL80I/V (27.3%,9/33), P=0.032]; while the HBV rtM204V mutations was significantly associated with HBV rtL180M mutations [rtM204V+rtL180M (100%, 33/33) vs. rtM204I+rtL180M (60.9%, 39/64), P<0.001]. 

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation