Mutation Information
Mutation Site
|
L180M |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.L180M+rt.M204I;rt.L180M+rt.L80V+rt.L80I+rt.M204I;rt.V173M+rt.L180M+rt.M204I;rt.L180M+rt.M204V;rt.L180M+rt.V173L+rt.M204V;rt.L180M+rt.L80V+rt.L80I+rt.M204V;rt.L180M+rt.V173L+rt.L80V+rt.L80I+rt.M204V;rt.A181T+rt.L180M+rt.M204V+rt.M204I;rt.L180M+rt.L80V+rt.L80I+rt.M204V+rt.M204I;rt.L180M+rt.V173L+rt.L80V+rt.L80I+rt.M204V+rt.M204I |
Country
|
China |
Literature Information
PubMed PMID
|
24160943
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2013 |
Journal
|
Virology journal |
Title
|
Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B. |
Author
|
Lei J,Wang Y,Wang LL,Zhang SJ,Chen W,Bai ZG,Xu LY |
Evidence
|
Among LAM/LdT based therapies, HBV rtM204I was significantly associated with HBV rtL80I/V mutations [rtM204I+rtL80I/V (50.0%, 32/64) vs. rtM204V+rtL80I/V (27.3%,9/33), P=0.032]; while the HBV rtM204V mutations was significantly associated with HBV rtL180M mutations [rtM204V+rtL180M (100%, 33/33) vs. rtM204I+rtL180M (60.9%, 39/64), P<0.001].
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