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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.T184L+rt.L180M;rt.M204V+rt.T184L+rt.L180M;rt.M204I+rt.T184L+rt.L180M |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
19125938
|
|
Disease
|
Chronic hepatitis B
|
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Published Year
|
2009 |
|
Journal
|
Hepatology research : the official journal of the Japan Society of Hepatology |
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Title
|
Spontaneous HBeAg seroconversion and loss of hepatitis B virus DNA after acute flare due to development of drug resistant mutants during entecavir monotherapy. |
|
Author
|
Mao RC,Yin YK,Qin YL,Wu XH,Weng XH,Zhang JM,Lu M |
|
Evidence
|
Interestingly, a new mutant type with rtL180M+rtT184L was found alongside rtL180M+rtT184L+rtM204V/I at week 228 and appeared to develop independently, according to the sequence analysis.
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HBV Mutation Detail Information