|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M |
|
Viral Reference
|
AY090460;
AF160501;
X75658;
X75657;
V01460;
X01587;
D00329;
X02763 |
|
Relevant Drug
|
lamivudine (LAM);telbivudine (LDT) |
|
Country
|
America |
Literature Information
|
PubMed PMID
|
21723325
|
|
Disease
|
HBV infection
|
|
Published Year
|
2011 |
|
Journal
|
Journal of virological methods |
|
Title
|
Development and validation of a hepatitis B virus DNA sequencing assay for assessment of antiviral resistance, viral genotype and surface antigen mutation status. |
|
Author
|
Mallory MA,Page SR,Hillyard DR |
|
Evidence
|
Mutations conferring resistance to lamivudine and telbivudine were most common (rtL180M and rtM204I/V) (74.3% of total mutant samples).
|
|
|
HBV Mutation Detail Information