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Mutation Information
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Mutation Site
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D83N |
|
Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
lamivudine (LAM) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
23114756
|
|
Clinical information
|
Yes
|
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Disease
|
HBV infection
|
|
Published Year
|
2013 |
|
Journal
|
Antimicrobial agents and chemotherapy |
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Title
|
Low-level persistence of drug resistance mutations in hepatitis B virus-infected subjects with a past history of Lamivudine treatment. |
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Author
|
Margeridon-Thermet S,Svarovskaia ES,Babrzadeh F,Martin R,Liu TF,Pacold M,Reuman EC,Holmes SP,Borroto-Esoda K,Shafer RW |
|
Evidence
|
Therefore, following alignment we excluded sequence reads considered to be hypermutated by one of the following three criteria (17): (i) ≥10% of nucleotide positions with a G in the population sequence but an A in the UDPS read, (ii) ≥2 unusual HBV RT variants caused by G-to-A differences (an unusual variant was defined as a variant present in fewer than three sequences from ∼4,000 different individuals with HBV RT sequences in GenBank) (18), or (iii) a stop codon or one of the following active site mutations rtD83N, rtD205N, and rtD206N.
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HBV Mutation Detail Information