HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.L180M+rt.M204V;rt.M204V+rt.L180M+rt.V173L;rt.M204V+rt.L180M+rt.V173L+rt.I169T;rt.L180M+rt.M204I+rt.M204V+rt.T184S;rt.L180M+rt.M204V+rt.M204I+rt.Q215S
Relevant Drug	lamivudine (LAM);entecavir (ETV);tenofovir (TDF);clevudine (L-FMAU)

Literature Information

PubMed PMID	16673294
Published Year	2006
Journal	Seminars in liver disease
Title	Antiviral drug resistance: clinical consequences and molecular aspects.
Author	Bartholomeusz A,Locarnini SA
Evidence	The rtM204I/V is selected by lamivudine and L-nucleosides. It is also part of the entecavir resistance profile and the tenofovir-lamivudine combination resistance profile. In contrast, resistance to adefovir is associated with mutations at rtN236T +/- rtA181V.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation