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Mutation Information
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Mutation Site
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A181T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Genotype/Subtype
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B;C;D |
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Relevant Drug
|
adefovir (ADV) |
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Country
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China |
Literature Information
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PubMed PMID
|
21392168
|
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Disease
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Chronic hepatitis B;
Liver cirrhosis
|
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Published Year
|
2011 |
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Journal
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Journal of viral hepatitis |
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Title
|
Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection. |
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Author
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Liu Y,Wang C,Zhong Y,Li X,Dai J,Ren X,Xu Z,Li L,Yao Z,Ji D,Wang L,Zhang L,Wong VW,Zoulim F,Xu D |
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Evidence
|
Of the resistance mutations detected in patients who received monotherapies, rtM204I (32.2%), rtM204V + L180M ± V173L (32.2%) and rtM204I + L180M ± V173L (21.0%) were dominant patterns for LAM; rtN236T + A181T and/or rtA181V (34.3%), rtN236T (31.4%) and rtA181V (28.6%) were dominant patterns for ADV, and mutations containing rtM204I were dominant patterns for LdT.
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HBV Mutation Detail Information