|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
21484148
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2011 |
|
Journal
|
Hepatology international |
|
Title
|
Extended treatment with lamivudine and adefovir dipivoxil in chronic hepatitis B patients with lamivudine resistance. |
|
Author
|
Perrillo RP,Hann HW,Schiff E,Mutimer D,Willems B,Leung N,Lee WM,Dixon S,Woessner M,Brosgart CL,Condreay LD,Gardner SD |
|
Evidence
|
Fifty-two percent of Group A patients on combination treatment continued to have the M204V/I HBV mutation compared to 92% receiving lamivudine alone (p = 0.0013).
|
|
|
HBV Mutation Detail Information