HBV Mutation Detail Information

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Mutation Information

Mutation Site	A181S
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Country	Germany

Literature Information

PubMed PMID	22892524
Disease	HBV infection
Published Year	2012
Journal	Antiviral therapy
Title	Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy.
Author	van Bömmel F,Trojan J,Deterding K,Wedemeyer H,Wasmuth HE,Hüppe D,Möller B,Bock FJ,Feucht HH,Berg T
Evidence	In patient b, the rtA181S variant, which was recently described to be associated with resistance against LAM and ADV, was detected in one patient in combination with the mutation rtN236T in 2 out of the 6 clones dur-ing the early treatment phase not in the follow-up sam-ples taken during TDF therapy

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation