Mutation Information
Mutation Site
|
T184S |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
entecavir (ETV) |
Country
|
Korea |
Literature Information
PubMed PMID
|
19578241
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2009 |
Journal
|
Antiviral therapy |
Title
|
Adefovir dipivoxil resistance patterns in patients with lamivudine-resistant chronic hepatitis B. |
Author
|
Santantonio T,Fasano M,Durantel S,Barraud L,Heichen M,Guastadisegni A,Pastore G,Zoulim F |
Evidence
|
Moreover, among patients without virological breakthrough, amino acid substittions at positions 184 and 250 (rtT184S/A and rtM250L) potentially associated with resistance to entecavir, and the controversial rtA194T mutation associated with resistance to tenofovir, were found in seven and one patients, respectively, who were treated with 3TC for a median period of 38 months (Figure 1).
|
|
|