Mutation Information
Mutation Site
|
G741A |
Mutation Type
|
Nucleotide level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.M204I+rt.L180M |
Nucleotide_Mutation
|
M204I |
Genotype/Subtype
|
C |
Relevant Drug
|
lamivudine (LAM) |
Literature Information
PubMed PMID
|
18713056
|
Disease
|
HBV infection
|
Published Year
|
2008 |
Journal
|
The Journal of infectious diseases |
Title
|
Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus. |
Author
|
Ohkawa K,Takehara T,Kato M,Deguchi M,Kagita M,Hikita H,Sasakawa A,Kohga K,Uemura A,Sakamori R,Yamaguchi S,Miyagi T,Ishida H,Tatsumi T,Hayashi N |
Evidence
|
The G739 and T/C/A741 mutations are the causes of the rtM204V and rtM204I amino acid changes, and the occurrences of these mutations differed between viral strains with and those without rtL180M (P < .001), as described above.
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