|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
14642631
|
|
Disease
|
HBV infection
|
|
Published Year
|
2003 |
|
Journal
|
Journal of hepatology |
|
Title
|
Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. |
|
Author
|
Villeneuve JP,Durantel D,Durantel S,Westland C,Xiong S,Brosgart CL,Gibbs CS,Parvaz P,Werle B,Trépo C,Zoulim F |
|
Evidence
|
RESULTS: Sequence analyses of the HBV polymerase gene revealed a sequential selection of lamivudine resistance mutations L180M+M204V, followed by a reversion to wild-type, and subsequently the selection of a novel adefovir resistance mutation N236T.
|
|
|
HBV Mutation Detail Information