HBV Mutation Detail Information

> N236T Search Result

Mutation Information

Mutation Site	N236T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Relevant Drug	adefovir (ADV)

Literature Information

PubMed PMID	12891527
Disease	Chronic hepatitis B
Published Year	2003
Journal	Gastroenterology
Title	Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.
Author	Angus P,Vaughan R,Xiong S,Yang H,Delaney W,Gibbs C,Brosgart C,Colledge D,Edwards R,Ayres A,Bartholomeusz A,Locarnini S
Evidence	In vitro testing of a laboratory strain encoding the rtN236T mutation and testing of patient-derived virus confirmed that the rtN236T substitution caused a marked reduction in susceptibility to adefovir.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation