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Mutation Information
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Mutation Site
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D541E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Country
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Iran |
Literature Information
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PubMed PMID
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31179360
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Disease
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Chronic hepatitis B
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Published Year
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2019 |
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Journal
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Virusdisease |
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Title
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Hepatitis B virus reverse transcriptase polymorphisms between treated and treatment-naïve chronically infected patients. |
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Author
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Rezanezhadi M,Mohebbi A,Askari FS,Hosseini SD,Tabarraei A |
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Evidence
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FI score of HBV polymerase substitution. Substitutions with low FI were Y592F (0.895), Y592H (0.895), E598N (1.15), H599R (1.67), Q602H (0.805), Q602P (1.15), K603R (1.845), R609I (1.525), L611H (1.67), P616T (1.845), C622G (1.845), I625M (1.67), V626G (1.525), L628F (1.67), G630A (1.67), F631L (1.845), and A632C (1.445). L629G/W had medium functional impact with FI score of 1.975. Further neutral substitutions with FI score of 0 were G442L, S444P, L457F, N459H/Y, M464L, P465Q/H, D466K/N, Y470S/L, L481S, H491Q, F501L, R502Q, L515M, A521V, I522L, V526I, A529V, M539V, D541E, S548T/N, V549A/E, Q550H/S/P, L552H/R, S554A, F556Y, V559A, I568V, N573H/S, K574R, K576Q, Y580H, N583H, I589G, E598D, and I601R. Further neutral substitutions were C591S (− 1.1), I601K/M (0.69), I601V (− 0.625), Q602L (0.255), E606D/K (0.345), and I613V (− 1.355);Only one case had D541E substitution. Among female patients, only 10.53% (4/38) had YMDD substitutions. ;Pearson correlation has shown significant relations between YMDD variations and substitutions M539I (R2 = 0.909; p < 0.0001), D541E (R2 = 0.260; p = 0.005), and LAM treatment (R2 = 0.287; p = 0.002).
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HBV Mutation Detail Information