|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
telbivudine (LDT) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
26382925
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2015 |
|
Journal
|
The Journal of general virology |
|
Title
|
Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment. |
|
Author
|
Yin F,Wu Z,Fang W,Wu C,Rayner S,Han M,Deng F,Du R,Liu J,Wang M,Wang H,Ning Q,Hu Z |
|
Evidence
|
Mutations rtM204I, rtL80I and rtL80V were detected in at least three of the four viral breakthrough patients, indicating the significant roles of the mutations in resistance to LDT.
|
|
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HBV Mutation Detail Information