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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B:C |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
24992206
|
|
Disease
|
Chronic hepatitis B
|
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Published Year
|
2015 |
|
Journal
|
Antiviral therapy |
|
Title
|
Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection. |
|
Author
|
Li X,Liu Y,Zhao P,Wang Y,Chen L,Xin S,Zhang XX,Xu D |
|
Evidence
|
RESULTS: Drug-resistant mutations were detected in 2.01% (17/845) of the patients by direct sequencing, including 15 with lamivudine-resistant mutations (rtM204V, rtM204I), one with adefovir-resistant mutation (rtA181V), and one with both lamivudine- and adefovir-resistant mutations (rtA181V, rtM204I).
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HBV Mutation Detail Information