|
Mutation Information
|
Mutation Site
|
V173L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V173L+rt.M204V+rt.L180M;rt.M250V+rt.V173L+rt.M204V+rt.L180M |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
28870025
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2017 |
|
Journal
|
Clinical and molecular hepatology |
|
Title
|
Clinical characteristics of patients with chronic hepatitis B who developed genotypic resistance to entecavir: Real-life experience. |
|
Author
|
Kim HJ,Cho YK,Jeon WK,Kim BI |
|
Evidence
|
The patterns of genotypic resistance to ETV were as follows: L180M + M204V + S202G (n=3); M204I + V173M (n=1); I169V + V173M (n=1); L180M + M204V + V173L (n=1); L180M + M204V + V173L + M250V (n=1); M204I + V214A + P237H (n=1).
|
|
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HBV Mutation Detail Information