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Mutation Information
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Mutation Site
|
L180M |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.M204V+rt.L180M;rt.M204I+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV);entecavir (ETV);telbivudine (LDT);clevudine (CLV) |
Literature Information
|
PubMed PMID
|
18765256
|
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Published Year
|
2008 |
|
Journal
|
Antiviral research |
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Title
|
Understanding the molecular basis of HBV drug resistance by molecular modeling. |
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Author
|
Sharon A,Chu CK |
|
Evidence
|
In this regard, homology modeled structure of HBV polymerase were used for minimization, conformational search and induced fit docking followed by binding energy calculation on wild type as well as on mutant-HBV polymerases (L180M, M204V, M204I, L180M+M204V, L180M-M204I).
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HBV Mutation Detail Information