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Mutation Information
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Mutation Site
|
V173L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.V173L;rt.M204V+rt.L180M+rt.V173L+rt.I169T |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
|
PubMed PMID
|
18571815
|
|
Disease
|
Chronic hepatitis B
|
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Published Year
|
2008 |
|
Journal
|
Hepatology (Baltimore, Md.) |
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Title
|
Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance. |
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Author
|
Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA |
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Evidence
|
Our in vitro data indicated that the reduced % dDNA observed in the presence of rtM204V/I could be restored to near wild-type levels by the compensatory mutation rtV173L.
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HBV Mutation Detail Information