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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L180M+rt.M204V;rt.V173L+rt.L180M+rt.M204V;rt.L180M+rt.M204I;rt.V173L+rt.L180M+rt.M204I;rt.V207I+rt.L180M+rt.M204I;rt.V207I+rt.V173L+rt.L180M+rt.M204I |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
16378967
|
|
Disease
|
HBV infection
|
|
Published Year
|
2006 |
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Journal
|
Journal of virology |
|
Title
|
Dynamics of hepatitis B virus resistance to lamivudine. |
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Author
|
Pallier C,Castéra L,Soulier A,Hézode C,Nordmann P,Dhumeaux D,Pawlotsky JM |
|
Evidence
|
The principal substitutions outside the YMDD motif were rtV173L and rtL180M (located outside the C domain), which have been reported to partially restore the in vitro replication capacity of variants with substitutions in the YMDD motif
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HBV Mutation Detail Information