|
Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M |
|
Viral Reference
|
AM282986
|
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV);telbivudine (LDT);clevudine (CLV) |
Literature Information
|
PubMed PMID
|
24814823
|
|
Published Year
|
2014 |
|
Journal
|
Current opinion in virology |
|
Title
|
Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance. |
|
Author
|
Menéndez-Arias L,Álvarez M,Pacheco B |
|
Evidence
|
Major mutational patterns conferring nucleoside/nucleotide analog resistance include the combinations rtL180M/rtM204(I/V) (for lamivudine, entecavir, telbivudine and clevudine) and rtA181V/rtN236T (for adefovir and tenofovir).
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HBV Mutation Detail Information