|
Mutation Information
|
Mutation Site
|
N238H |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N238H+rt.S219A |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
NC_003977
|
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
25989376
|
|
Disease
|
Chronic hepatitis B;
Acute hepatitis B
|
|
Published Year
|
2015 |
|
Journal
|
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |
|
Title
|
Impact of HBV genotypes A and D genetic variability on infection evolution. |
|
Author
|
Urone N,Di Marco V,Cacopardo B,Craxì A,Ferraro D |
|
Evidence
|
Secondary mutations on RT-domain associated with resistance to nucleos(t)idic analogues were identified in 22 HBV-D and in 1 HBV-A2 isolates: rtV214A, rtV214E, rtQ215H, rtS219A + rtN238H in 4 isolates (9%) from AHB and rtA200V/G, rtV214A/E, rtQ215H/S/P, rtS219A, rtI233V, rtN238H in 19 (41%) CHB isolates were identified.
|
|
|
HBV Mutation Detail Information