Mutation Information
Mutation Site
|
M204V |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.M204V+rt.N236T |
Relevant Drug
|
lamivudine;telbivudine |
Country
|
China |
Literature Information
PubMed PMID
|
33986897
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2021 |
Journal
|
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale |
Title
|
High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy. |
Author
|
Wang J,Liu J,Yu Q,Jin L,Yao N,Yang Y,Yan T,Hu C,He Y,Zhao Y,Chen T,Zheng J |
Evidence
|
Results: Before TBV treatment, the complexity of HBV quasispecies of all subjects was 0.40 +- 0.09; 41.1% (30/73) and 53.4% (39/73) subjects had rtM204I/V and rtN236 T/A detected, respectively; and 9.6% (7/73) patients had more than 20% frequency mutation of rtM204I/V, which was also similar with high frequency of rtN236 T/A mutation (41.1% vs.
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