|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
X72702;
AY796031;
AY741796;
AY661792;
AY796030;
AY721605 |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Turkey |
Literature Information
|
PubMed PMID
|
24630522
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Diagnostic microbiology and infectious disease |
|
Title
|
Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method. |
|
Author
|
Ciftci S,Keskin F,Cakiris A,Akyuz F,Pinarbasi B,Abaci N,Dincer E,Badur S,Kaymakoglu S,Ustek D |
|
Evidence
|
Two of the 4 patients developed drug resistance after LAM therapy. The resistance mutations (M204I and L80V+L80I+L180M+M204I) were detected after 6 months of treatment. Viral isolates before treatment from both individuals (patient B2 and B3) carried the rtT128I (ratio; 10.4% and 18.2%) and rtC256S (ratio; 15.3% and 21.6%) putative antiviral resistance mutations against LAM.
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|
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HBV Mutation Detail Information