|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV) |
|
Country
|
Pakistan;China |
Literature Information
|
PubMed PMID
|
27535686
|
|
Disease
|
HBV infection
|
|
Published Year
|
2016 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Detection of Anti-Hepatitis B Virus Drug Resistance Mutations Based on Multicolor Melting Curve Analysis. |
|
Author
|
Mou Y,Athar MA,Wu Y,Xu Y,Wu J,Xu Z,Hayder Z,Khan S,Idrees M,Nasir MI,Liao Y,Li Q |
|
Evidence
|
The two-reaction assay had a limit of detection of 5 copies per reaction and could detect a minor mutant population (5% of the total population) with the reverse transcriptase M204V amino acid mutation in the presence of the major wild-type population when the overall concentration was 10(4) copies/mul.
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HBV Mutation Detail Information