HBV Mutation Detail Information

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Mutation Information

Mutation Site	N236T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	C
Relevant Drug	lamivudine (LAM);adefovir (ADV)
Country	Japan

Literature Information

PubMed PMID	21503906
Disease	Chronic hepatitis B
Published Year	2011
Journal	Journal of medical virology
Title	Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients.
Author	Aizawa M,Tsubota A,Fujise K,Tatsuzawa K,Kono M,Hoshina S,Tajiri H
Evidence	In clinical and in vitro study, the rtA181T/V mutation reduced the susceptibility not only to LAM, but also to ADV [Qi et al., 2006; Villet et al., 2008].

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation