|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
23710315
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2013 |
|
Journal
|
Gut and liver |
|
Title
|
Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B. |
|
Author
|
Kim DY,Chang HY,Lim SM,Kim SU,Park JY,Kim JK,Lee KS,Han KH,Chon CY,Ahn SH |
|
Evidence
|
However, it is associated with high rates of viral resistance; the prevalence of genotypic resistance after 8 years was 76%. The main mutation associated with LAM resistance is rtM204I/V.
|
|
|
HBV Mutation Detail Information