|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
15872296
|
|
Disease
|
HBV infection
|
|
Published Year
|
2005 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Prevalence, incidence, and clinical relevance of the reverse transcriptase V207I mutation outside the YMDD motif of the hepatitis B virus polymerase during lamivudine therapy. |
|
Author
|
Zöllner B,Sterneck M,Wursthorn K,Petersen J,Schröter M,Laufs R,Feucht HH |
|
Evidence
|
One additional patient carried wild-type HBV at baseline, but the rtV207I mutation emerged at month 24 of treatment in combination with the rtL180M and rtM204V exchanges.
|
|
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HBV Mutation Detail Information