|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
18504191
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
|
Title
|
[Mutations of HBV polymerase gene sequence in lamivudine-resistant chronic hepatitis B patients]. |
|
Author
|
Wang C,Sun J,Chen JJ,Wang ZH,Hou JL |
|
Evidence
|
Lamivudine resistant mutation was detected in 103 patients, and the major mutations included rtL180M+rtM204V and rtM204I, accounting for 58.3% and 22.3%, respectively. Other resistant substitutions included rtL80V/I, rtT184S, and rtA200V, and combined mutation of triple resistant substitutions was detected in HBV RT region of 5 patients by direct sequencing.
|
|
|
HBV Mutation Detail Information