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Mutation Information
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Mutation Site
|
P440L |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
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PubMed PMID
|
10762559
|
|
Clinical information
|
Yes
|
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Disease
|
Chronic hepatitis B
|
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Published Year
|
2000 |
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Journal
|
The Journal of infectious diseases |
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Title
|
Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B. |
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Author
|
Seignères B,Pichoud C,Ahmed SS,Hantz O,Trépo C,Zoulim F |
|
Evidence
|
By comparison with the consensus sequence of the RT domain among the different viral genotypes (figure 3), only 15 amino acid changes were found to be related to antiviral treatment: the L528M mutation (domain B), detected in 2 of the 4 patients with breakthrough of virus (1 responder and 1 nonresponder) and already described in famciclovir-resistant strains, and 14 novel mutations detected in 7 patients, 3 (N419T, A529V, and V539I) in 2 responders and 11 (T418S, A434P, P440L, H448N, L450I, L450V, L463F, H481Q, V555E, N596T, and V601E) in 5 nonresponders.
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HBV Mutation Detail Information