|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V173L+rt.L180M+rt.M204V |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
18624719
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2008 |
|
Journal
|
Hepatology research : the official journal of the Japan Society of Hepatology |
|
Title
|
Occult hepatitis B virus infection in HIV-infected patients: Evaluation of biochemical, virological and molecular parameters. |
|
Author
|
Araujo NM,Branco-Vieira M,Silva AC,Pilotto JH,Grinsztejn B,de Almeida AJ,Trepo C,Gomes SA |
|
Evidence
|
All clones derived from patient P51, as well as the directly sequenced PCR product, showed the lamivudine resistance mutation rtM204V within the YMDD motif of HBV DNA polymerase, intrinsically associated to I195M substitution in the HBsAg gene.
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HBV Mutation Detail Information