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Mutation Information
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Mutation Site
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V191I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Genotype/Subtype
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A |
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Country
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Spain |
Literature Information
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PubMed PMID
|
22666402
|
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Disease
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Chronic hepatitis B
|
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Published Year
|
2012 |
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Journal
|
PloS one |
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Title
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Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome. |
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Author
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Rodriguez-Frías F,Tabernero D,Quer J,Esteban JI,Ortega I,Domingo E,Cubero M,Camós S,Ferrer-Costa C,Sánchez A,Jardí R,Schaper M,Homs M,Garcia-Cehic D,Guardia J,Esteban R,Buti M |
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Evidence
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As observed in the baseline quasispecies, a significant portion of the 20 most frequent variants (highest average substitution frequencies in the 5 samples) led to stop codons (sW156*, sW172*, sW182*, sW191*, sW196* and sW199*), especially at LMV VBK and at the end of ADV, mainly due to mutation sW172*, related to rtA181T, (71.7% and 64%, respectively) and sW182*, related to rtV191I, (5.8% and 8%, respectively).
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HBV Mutation Detail Information