|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.S202I+rt.V191G+rt.Q182H+rt.L180M+rt.V173L+rt.V163P;rt.D263E+rt.M204V+rt.L180M;rt.M204I+rt.L180M+rt.S176N+rt.Q130P+rt.F122L+rt.L80I;rt.V278I+rt.I253V+rt.R217L+rt.M204V+rt.T184S+rt.L180M+rt.V163I+rt.W153R+rt.M129L+rt.N122H;rt.E271H+rt.I266V+rt.S259T+rt.Y257W+rt.V253I+rt.F221Y+rt.L217R+rt.M204V+rt.L180M+rt.I163V+rt.R153W+rt.F151Y+rt.F122N+rt.V103I;rt.E271D+rt.M204I+rt.A200V+rt.L180M;rt.I266V+rt.D263E+rt.M204V+rt.L180M+rt.L164M+rt.T128A+rt.F122L;rt.M204V+rt.L180M;rt.E271H+rt.I266V+rt.S259T+rt.Y257W+rt.V253I+rt.F221Y+rt.M204V+rt.L180M+rt.V173L+rt.I163V+rt.R153W+rt.F151Y+rt.L145M+rt.V142D;rt.S259A+rt.M250V+rt.M204V+rt.L180M+rt.L164M+rt.V142E+rt.T128I;rt.Y257W+rt.N238A+rt.P237T+rt.Q215S+rt.V214A+rt.M204V+rt.L180M+rt.R153W;rt.Q267H+rt.D263E+rt.M204V+rt.L180M+rt.I163V+rt.Q130P;rt.M204V+rt.L180M+rt.V142A+rt.T128I+rt.F122L |
|
Genotype/Subtype
|
A;D |
|
Relevant Drug
|
lamivudine (LAM);tenofovir (TDF);adefovir dipivoxil (ADV);emtricitabine (FTC);entecavir (ETV) |
|
Country
|
Rome |
Literature Information
|
PubMed PMID
|
19442845
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2009 |
|
Journal
|
Journal of virological methods |
|
Title
|
A sensitive direct sequencing assay based on nested PCR for the detection of HBV polymerase and surface glycoprotein mutations. |
|
Author
|
Vincenti D,Solmone M,Garbuglia AR,Iacomi F,Capobianchi MR |
|
Evidence
|
Table 1
|
|
|
HBV Mutation Detail Information