HBV Mutation Detail Information

> V173L Search Result

Mutation Information

Mutation Site	V173L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Viral Reference	X75665.1
Relevant Drug	lamivudine (LAM)
Country	Japan;United States; Hong Kong

Literature Information

PubMed PMID	19933798
Disease	Chronic hepatitis B
Published Year	2010
Journal	Antimicrobial agents and chemotherapy
Title	Mechanism of entecavir resistance of hepatitis B virus with viral breakthrough as determined by long-term clinical assessment and molecular docking simulation.
Author	Mukaide M,Tanaka Y,Shin-I T,Yuen MF,Kurbanov F,Yokosuka O,Sata M,Karino Y,Yamada G,Sakaguchi K,Orito E,Inoue M,Baqai S,Lai CL,Mizokami M
Evidence	Among the patients examined at entry prior to treatment with ETV, in 41 LVD-refractory patients, M204V (30/41; 72.4%), M204I (24/41; 58.5%), L180M (38/41; 92.7%), L80V (6/41; 14.6%), L80I (18/41; 43.9%), and V173L (4/41; 9.76%) substitutions were detected.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation