|
Mutation Information
|
Mutation Site
|
M250L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M250L+rt.M250I+rt.M250V+rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V;rt.M250L+rt.M250I+rt.M250V+rt.M204I+rt.M204V;rt.M250L+rt.M250I+rt.M250V+rt.S202C+rt.S202G+rt.T184I+rt.T184S+rt.T184A+rt.T184L+rt.T184F+rt.T184G+rt.M204I+rt.M204V+rt.N236T+rt.A181V |
|
Genotype/Subtype
|
B;C |
|
Relevant Drug
|
entecavir (ETV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
27792585
|
|
Disease
|
HBV infection
|
|
Published Year
|
2017 |
|
Journal
|
Microbial drug resistance (Larchmont, N.Y.) |
|
Title
|
Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China. |
|
Author
|
Li X,Liu Y,Xin S,Ji D,You S,Hu J,Zhao J,Wu J,Liao H,Zhang XX,Xu D |
|
Evidence
|
For entecavir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtM204 V/I+T184 substitution or S202G/C (3.66% vs. 2.16%, p < 0.01) and a lower detection rate of rtM204 V/I+M250 V/I/L substitution (0.67% vs. 1.46%, p < 0.01).
|
|
|
HBV Mutation Detail Information